内容来源：https://blog.google/around-the-globe/google-asia/researchers-asia-pacific-alphafold-five-years/

内容总结：

【前沿】亚太科学家借助AlphaFold推动生命科学突破性进展

在生命科学领域，蛋白质作为驱动所有生物活动的微观机器，其三维结构决定功能特性。过去数十年间，解析蛋白质结构始终面临耗时久、成本高的困境。五年前问世的AlphaFold人工智能系统通过氨基酸序列即可精准预测蛋白质三维构象，目前全球逾300万研究人员使用该技术，其中超三分之一集中在亚太地区。以下是该区域科学家取得的五项代表性突破：

1. 马来西亚：阻击"隐形杀手"类鼻疽病
   国立大学苏达特·拉姆博士团队运用AlphaFold解析伯克霍尔德杆菌的致病蛋白结构，揭示其通过污染水土传播的机制，为每年导致近9万人死亡的类鼻疽病药物研发按下"加速键"。

2. 新加坡：破解帕金森病新线索
   科技研究局与国立神经科学研究院团队通过AlphaFold构建帕金森相关蛋白三维模型，首次揭示人体免疫系统如何干扰蛋白质功能，为早期诊断与靶向治疗开辟新路径。

3. 韩国：捕捉癌症致病元凶
   韩国科学技术院宋智昀团队成功绘制关键蛋白的未知功能区域，发现导致DNA结构紊乱引发癌症的隐藏作用位点。研究人员评价"AlphaFold如同结构生物学领域的互联网"。

4. 中国台湾：发现蛋白质新构型
   中央研究院徐德团队利用AlphaFold预测出具有71个交叉环的复杂蛋白质拓扑结，实验验证该全新三维结构，证明人工智能助力发现未知自然现象的能力。

5. 日本：深海热泉现生命新谱系
   浦山俊一团队在热泉微生物研究中发现特殊病毒，经AlphaFold解析蛋白质结构后，确认其属于前所未有的生命家族，为分子进化史增添新分支。

目前亚太地区已有逾1.3万篇论文引用该项技术。从应对罕见疾病到探索生命起源，AlphaFold正推动全球科研共同体以前所未有的速度应对人类健康重大挑战。该技术核心研发者德米斯·哈萨比斯与约翰·詹珀因相关贡献共同荣获2024年诺贝尔化学奖。

中文翻译：

亚洲科研人员如何运用AlphaFold推动科学突破
蛋白质是驱动几乎所有生命活动的微观机器——从人体抗病机制到生命演化进程都离不开它。这些微观机器的功能由其独特的三维结构决定，但过去数十年间，绘制蛋白质结构图始终是一项耗时耗力的工作。五年前，我们推出了仅凭氨基酸序列即可精准预测蛋白质结构的AI系统AlphaFold，并向全球免费开放。

如今AlphaFold已吸引逾三百万研究人员使用，其中超过三分之一集中在亚太地区。从对抗致命疾病到发现全新生命形态，让我们通过五个案例了解亚太科学家如何借助这项技术在医学与科学领域取得突破：

1. 马来西亚抗击"隐形杀手"
   类鼻疽病由伯克霍尔德氏菌引起，患者通常通过接触受污染的土壤或水源感染，每年导致近9万人死亡。马来西亚国立大学的Su Datt Lam博士团队运用AlphaFold解析细菌蛋白质的生存传播机制，为抗击这种"隐形杀手"加速新药研发。

2. 新加坡破解帕金森病新线索
   新加坡科技研究局与国立神经科学研究院的研究员Jackwee Lim和Yinxia Chao利用AlphaFold构建了与帕金森病相关的蛋白质三维模型，首次揭示人体免疫系统如何干扰该蛋白质功能，为早期诊断与靶向治疗开辟新途径。

3. 韩国揭示疾病隐形推手
   韩国科学技术院Ji-Joon Song教授团队通过AlphaFold绘制出关键蛋白质中以往不可见的区域，发现隐藏的相互作用位点，推动DNA结构异常引发癌症等疾病的研究。正如他所言："AlphaFold如同结构生物学领域的互联网"。

4. 台湾探索蛋白质结构新前沿
   中央研究院Danny Hsu博士团队运用AlphaFold研究未知结构蛋白质时，预测出呈现"71环面纽结"的极端复杂折叠构象。后续实验证实了这一预测，展现出AI帮助科学家发现全新现象的能力。

5. 日本温泉发现生命新形态
   在研究日本温泉微生物时，Syun-ichi Urayama博士团队发现特殊病毒。通过AlphaFold预测其蛋白质结构，最终确认这些病毒属于一个此前未知的广泛生命家族，揭示了分子进化树的新分支。

这五个案例仅展现了亚太地区（相关论文超1.3万篇）科研成就的冰山一角。从攻克冷门疾病到揭示演化历史，AlphaFold已彻底改变生物学研究范式，推动全球科学家加速应对人类重大挑战。

关于AlphaFold的更多进展——包括其开发者德米斯·哈萨比斯与约翰·詹珀共同荣获2024年诺贝尔化学奖的详情，请访问Google DeepMind博客。

英文来源：

Here’s how researchers in Asia-Pacific are using AlphaFold
Proteins are the microscopic machines that drive nearly every biological process, from how our bodies fight disease to how life itself evolves. Their function is defined by their unique 3D shape, but for decades, mapping that shape was a slow and expensive process. Five years ago, we introduced AlphaFold, an AI system that accurately predicts protein structures based solely on their amino acid sequences, and made it freely available to the world.
Today, AlphaFold is used by over three million researchers, with more than a third of them in the Asia-Pacific region alone. From tackling deadly diseases to discovering entirely new forms of life, here are five ways researchers in this region have used AlphaFold to make breakthroughs in medicine and science:

1. Fighting a ‘silent killer’ in Malaysia
   Melioidosis, a disease caused by the bacterium Burkholderia pseudomallei — most commonly contracted through contaminated soil or water — claims nearly 90,000 lives each year. At the National University of Malaysia, Dr. Su Datt Lam’s team is using AlphaFold to understand how the bacterium’s proteins help it survive and spread, accelerating the development of new drugs to combat this "silent killer."
2. Uncovering new clues to Parkinson’s disease in Singapore
   Researchers Jackwee Lim and Yinxia Chao at Singapore’s Agency for Science, Technology and Research (A*STAR) and National Neuroscience Institute (NNI) used AlphaFold to create a 3D visualization of a protein linked to Parkinson's, a neurodegenerative disease. This revealed how the body's own immune system can disrupt the protein’s function, opening new paths for earlier diagnosis and targeted therapies.
3. Seeing the invisible drivers of disease in Korea
   At Korea’s Advanced Institute of Science & Technology (KAIST), Professor Ji-Joon Song’s team studies how disruptions in the way DNA is organized can lead to cancer and other diseases. AlphaFold allowed his team to map previously unseen regions of a key protein, uncovering a hidden interaction site. As he puts it, "AlphaFold is like the internet for structural biology."
4. Discovering a new frontier of protein shapes in Taiwan
   Dr. Danny Hsu’s team at Academia Sinica used AlphaFold to study a protein of unknown structure, and predicted a "71-torus knot" — an exceptionally complex protein fold. The team later confirmed this prediction in the lab, proving AlphaFold can help scientists discover entirely new phenomena.
5. Finding new life in Japan’s hot springs
   While studying microbes in the hot springs of Japan, Dr. Syun-ichi Urayama’s team discovered unusual viruses. Using AlphaFold to predict their protein structures, the team confirmed they belonged to a widespread, previously unknown family of life, revealing a new branch of molecular evolution.
   These five stories from the Asia-Pacific region — where we have over 13,000 research papers citing AlphaFold — represent just a fraction of what scientists have discovered since we introduced the technology. From tackling neglected diseases to revealing evolutionary history, AlphaFold has fundamentally changed biological research, empowering a global community of scientists to accelerate their work and tackle humanity's greatest challenges.
   Learn more about AlphaFold — including the co-award of the 2024 Nobel Prize in Chemistry to Demis Hassabis and John Jumper for its development — on the Google Deepmind blog.